CHEM 263 - Chapter 4

Created by Ameera Gani

In an EAS, what is the nucleophile?
Aromatic ring

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TermDefinition
In an EAS, what is the nucleophile?
Aromatic ring
What does the nucleophile use to attack the electrophile?
Pi e- (DB)
What is the RDS in an EAS? Why?
- The first step is RDS - Aromaticity is being disrupted = unfavorable = slow
Anything to stabilize the TS will _____ the rxn rate
Speed up
T/F: The carbocation intermediate of an EAS is not resonance stabilized
False
Is the final step of an EAS fast or slow? Why?
- Fast - Restores aromaticity
Intermediate vs TS
Intermediate: species that exists between R and P in a state corresponding to energy MINIMUM TS: High energy arrangement that represents bonds breaking/forming during mechanism
What is the product of aa FC alkylation?
Alkylbenzene (PhR)
What is an FC alkylation activated by? Why
Lewis Acid - AlCl3, FeBr3 Alkyl halide is made more electrophilic w/ lewis acid
What solveny you need for a FC alkylation?
Lewis acid + alkyl halide
For primary alkyl halides, what is the electrophile?
Lewis acid-alkyl halide together
For secondary and tertiary alkyl halides, what is the electrophile?
The carbocation
T/F: Primary carbocations are stable
False, they're very unstable
What will FC alkylation's not react with? Why? 2
Vinyl or aromatic halides - Cannot participate bc halide is already on an sp2 carbon
T/F: any conditions that generate carbocations can lead to FCA
True
Alkene + acid =
Carbocation
What 3 things will only react in FCA?
- Benzene - Halobenzene - Electron rich benzene
Does overalkylation occur? Why?
Yes - Alkyl groups are EDG = aromatic ring is more e- rich and more nucleophilic
T/F: EWG are not good for FC rxns
True
What conditions do you need for oxidation to generate a CA at benzylic carbon?
1. KMnO4, KOH, heat 2. H3O+
The oxidation rxn converts a _______ to an ______
EDG (alkyl) to a EWG (CA)
What is the product of an FC acylation rxn?
Acylbenzene (PhCOR)
What two things does an FC acylation occur between? What is it activated by?
- Acid halide/anhydride and benzene - Lewis acid
What is the electrophile in the FC acylation rxn?
Acylium ion
Is overacylation a problem? Why?
No - Acyl groups are EWG = aromatic ring is e- poor and less nucleophilic
What is used in the Clemmensen reduction?
- ZnHg - HCl
What is done in the Clemmensen reduction?
Reduce a C=O to a methylene (CH2) group
The Clemmensen reduction converts a ____ to a ____
EWG (acyl) to a EDG (alkyl)
What activates Br2 during bromination? Why?
FeBr3 - Makes it more electrophilic
What do you need for a bromination rxn?
Br2 FeBr3
What do you need for a chlorination rxn?
Cl2 AlCl3
What are the end products of bromination? 3
Bromobenzene HBr FeBr3
What are the end products of chlorination? 3
Chlorobenzene HCl AlCl3
What do you need for an iodination rxn?
I2 HNO3
What are the end products of iodination?
Iodobenzene NO2 H2O
What is the nitration rxn accelerate by?
H2SO4
What do you need for a nitration rxn?
HNO3 H2SO4
How can nitrobenzene be reduced to anilines?
- Zn, HCl OR - H2, Pd
The reduction of nitrobenzene to aniline converts a ____ to a _____
EWG (NO2) to a EDG (NH2)
What do you need for the sulfonation rxn?
SO3 H2SO4
Is sulfonation reversible?
Yes
How can you remove HSO3 from benzene?
H2SO4 Steam (H2O + heat)
T/F: the less e- density in the ring, the better the nucleophile
False
EDG ______ reactivity
Increase
Are activators EDG or EWG?
EDG
EWG _____ reactivity
Reduce
Which effects are more significant? Resonance or induction?
Resonance
What are the strongest to weakest activators? 6
1. O- 2. NH2 3. OH 4. OR 5. NHCOR 6. R
What are the strongest to weakest deactivators?
1. NO2 2. HSO3 3. CN 4. COR 5. COOR 6. NR3+
For alkyl sub, what substitution would you see?
O/P - Para for big groups
Increase in the size of alkyl groups mean it goes from ____ to _______
Ortho to para
Alkyl groups are ______, ________ - Directing groups
Activating, O/P
Methoxy groups are electron______ and ____ the reactivity of benzene
Donating groups and enhance
Methoxy groups are _______, ______-Directing groups
Activating, O/P
Amino groups are electron______ and ____ reactivity of benzene
Donating and enhance
Ammonium groups are electron__________
Withdrawing
The amino group is ________, _________-Directors
Activating, O/P
Nitro groups are electron________(_____&____) and _____ reactivity of benzene
- Withdrawing (resonance & induction) - Decrease reactivity
If you have a decreased reactivity, will the rxn go slower or faster?
Slower
EWG ______ the carbocation intermediate = _____ rate of rxn
- Destabilize - slower
For EWG, which intermediate is harder to form?
High energy
Nitro groups are _______, ________-directors
Deactivating, meta
What are some EWG? 5
- Ketones, esters, nitriles, sulfonic acid, ammonium salt
Halobenzenes are _____ to react than benzene
Slower
How can halogens influence EAS rxns? 2
1. They are electronegative and deactivate the ring inductively 2. Donate e- density via resonance and activate through formation of halonium ions
Halogens are _______, ________-directors
Deactivating, O/P
Should you place a new group between substituents?
NO
If two substituents on a benzene ring have opposing effects, what are the 3 ways you decide where to place the new sub?
1. Strongest activator wins: OP directors that stabilize carbocation's through resonance 2. Intermediate directors: OP directors 3. Strongest deactivators are the weakest
In NAS, what is the electrophile?
The ring
Compounds that undergo EAS are electron-________, and those that undergo NAS are electron_________
- electron rich - Electron poor
When is addn-elim common?
When one+ EWG located OP to substitution site
EWG oriented in ______ position have left effect
Meta
When is the benzyne mechanism appropriate?
In rings w/o many EWG